HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 14369620, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Diethyl-(2-piperidin-2-yl-ethyl)-amine | HCID 6484179 | — |
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Cyclohexane ethyl acetate methanol | HCID 22064753 | — |
| Product | HCID 14369620 | HCID 14369620 | 37% |
Reaction Steps
Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[2-(diethylamino)ethyl]piperidine in a yield of 37% of theory. Colourless crystals, m.p. 100° C. (D.) (from acetonitrile), Rf 0.25 (Macherey-Nagel, Polygram® SIL G/UV254, pre-coated plastic sheets for TLC; eluant: dichloromethane/,ethyl acetate/cyclohexane/methanol/conc. ammonia 57/25/8/8/1, v/v/v/v/v)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-6559110c3f3b405d904678ec4a2a26f2 |
| Source note | uspto-grants-1990_06 |