HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5,11-Dihydro-11-[[2-[2-(dimethylamino)ethyl]-1-piperidinyl]-carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Dimethyl-(2-piperidin-2-yl-ethyl)-amine | HCID 296295 | — |
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Solvent | Dichloromethane cyclohexane methanol | HCID 69163855 | — |
| Product | 5,11-Dihydro-11-[[2-[2-(dimethylamino)ethyl]-1-piperidinyl]-carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 14369621 | 37% |
Reaction Steps
Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[2-(dimethylamino)ethyl]piperidine in a yield of 37% of theory. Colourless crystals, m.p. 188°-190° C. (from acetonitrile), Rf 0.6 (Macherey-Nagel, Polygram® SIL G/UV254, pre-coated plastic sheets for TLC; eluant: dichloromethane/cyclohexane/ methanol/conc. ammonia 68/15/15/2, v/v/v/v).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-0e92582e96ad4cd6bd0adca54ef29b88 |
| Source note | uspto-grants-1990_06 |