HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 14369624, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Reactant | HCID 15057317 | HCID 15057317 | — |
| Solvent | HCID 86583941 | HCID 86583941 | — |
| Product | HCID 14369624 | HCID 14369624 | 55% |
Reaction Steps
Prepared analogously to Example 4 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[4-(dimethylamino)butyl]piperidine in a yield of 55% of theory. Colourless crystals, m.p. 145°-147° C. (from ethyl acetate), Rf 0.1 (Macherey-Nagel, Polygram® SIL G/UV254, pre-coated plastic sheets for TLC; eluant: dichloromethane/ethyl acetate/cyclohexane/methanol/conc. ammonia 58/25/8/8/1, v/v/v/v/v)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-5938faca13964d7597e4c4529fe51527 |
| Source note | uspto-grants-1990_06 |