11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → HCID 14369632, compound

HRID 2106679Notes

Reaction equation

HRID 2106679 reaction equation
[Cl:1][C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[CH2:20]([N:22]([CH2:32][CH3:33])[CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][NH:28][CH2:27]1)[CH3:21].C(O)C.C(OC(C)C)(C)C>>[ClH:1].[CH2:32]([N:22]([CH2:20][CH3:21])[CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][N:28]([C:2]([N:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8](=[O:15])[NH:7][C:6]3[CH:16]=[CH:17][CH:18]=[N:19][C:5]2=3)=[O:3])[CH2:27]1)[CH3:33]

Participants

4

Reactant 3

HCID 1104396211-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 150573013-[3-(Diethylamino)propyl]piperidineHCID 23358034HCID 23358034, compound

Product 1

HCID 14369632HCID 14369632, compoundYield 84%

Procedure

Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 3-[3-(diethylamino)propyl]piperidine in a yield of 84% of theory. Colourless crystals, m.p. 257°-258° C. (ethanol/diisopropylether)

Sources & evidence

ORD record
ord-5319eb66dd0b46098dccf8f67a5a58b5
Source dataset
uspto-grants-1990_06
Patent number
US04931436

Reaction notes

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