HuagongsheHuagongshe Chemistry Print Report · For research reference only
11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → 5,11-Dihydro-11-[[3-[3-(1-pyrrolidinyl)propyl]-1-piperidinyl]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Reactant | 3-[3-(Pyrrolidin-1-yl)propyl]piperidine | HCID 15057305 | — |
| Reactant | Propan-2-one--water (1/1) | HCID 18366337 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5,11-Dihydro-11-[[3-[3-(1-pyrrolidinyl)propyl]-1-piperidinyl]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one-hydrochloride | HCID 14369640 | 56% |
Reaction Steps
Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 3-[3-(1-pyrrolidinyl)propyl]piperidine in a yield of 56% of theory. Colourless crystals, m.p. >260° C. (from water/acetone), water solubility: about 0.3%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-2765767ce5014e61bcfebad1c61d1721 |
| Source note | uspto-grants-1990_06 |