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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2106683Generated: October 25, 2026

11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → 5,11-Dihydro-11-[[3-[2-(dipropylamino)ethyl]-1-piperidinyl]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one-hydrochloride

https://huagongshe.com/reaction/2106683

Reaction equation

Participants

RoleNameHCIDCharge
Reactant11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 11043962—
Reactant3-[2-(Dipropylamino)ethyl]piperidineHCID 15057306—
SolventEthanolHCID 702—
Product5,11-Dihydro-11-[[3-[2-(dipropylamino)ethyl]-1-piperidinyl]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one-hydrochlorideHCID 1436964367%

Reaction Steps

Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 3-[2-(dipropylamino)ethyl]piperidine in a yield of 67% of theory. Colourless crystals, m.p. 202°-205° C. (ethanol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04931436
Source datasetuspto-grants-1990_06
ORD IDord-823239b63d7a425ba96b4a8dde05c596
Source noteuspto-grants-1990_06