HuagongsheHuagongshe Chemistry Print Report · For research reference only
11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one → 11-[[3-[2-[(Cyclopentyl)methylamino]ethyl]-1-piperidinyl]carbonyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one | HCID 14209983 | — |
| Reactant | 3-[2-[(Cyclopentyl)methylamino]ethyl]piperidine | HCID 15057309 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 11-[[3-[2-[(Cyclopentyl)methylamino]ethyl]-1-piperidinyl]carbonyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one | HCID 15057339 | 61% |
Reaction Steps
Prepared analogously to Example 4 from 11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one and 3-[2-[(cyclopentyl)methylamino]ethyl]piperidine in a yield of 61% of theory. Colourless crystals, m.p. 148°-150° C. (acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-9e2bd5e41a6347d996326345e5ea0e56 |
| Source note | uspto-grants-1990_06 |