HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 11-[[3-[2-[(Cyclopentyl)methylamino]ethyl]-1-piperidinyl]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Reactant | 3-[2-[(Cyclopentyl)methylamino]ethyl]piperidine | HCID 15057309 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 11-[[3-[2-[(Cyclopentyl)methylamino]ethyl]-1-piperidinyl]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one-hydrochloride | HCID 70373764 | 54% |
Reaction Steps
Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 3-[2-[(cyclopentyl)methylamino]ethyl]piperidine in a yield of 54% of theory. Colourless crystals, m.p. 244°-246° C. (ethanol), Rf 0.31 (Merck DC ready made TLC plates, silica gel 60 F254 ; eluant: dichloromethane/methanol/conc. ammonia 90/10/1, v/v/v).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-e63a51d7c7554e4ba3241357eb5c1db3 |
| Source note | uspto-grants-1990_06 |