HuagongsheHuagongshe Chemistry Print Report · For research reference only
11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → 5,11-Dihydro-11-[[3-[2-(hexahydro-1H-1-azepinyl)ethyl]-1-piperidinyl]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Reactant | 3-[2-(hexahydro-1H-1-azepinyl)ethyl]piperidine | HCID 15057314 | — |
| Reactant | Ethanol acetone water | HCID 86654442 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 5,11-Dihydro-11-[[3-[2-(hexahydro-1H-1-azepinyl)ethyl]-1-piperidinyl]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one-hydrochloride | HCID 14369657 | 78% |
Reaction Steps
Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 3-[2-(hexahydro-1H-1-azepinyl)ethyl]piperidine in a yield of 78% of theory. Colourless crystals, m.p. 255°-257° C. (ethanol/water/acetone 45/5/50, v/v/v), Rf 0.27 (Merck DC ready made TLC plates, silica gel 60 F254 ; eluant: dichloromethane/methanol/conc. ammonia 90/10/1, v/v/v).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-c5ba24020e554c258fc2ba6af49ab0ce |
| Source note | uspto-grants-1990_06 |