HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one → 4,9-Dihydro-4-[[3-[3-(dimethylamino)propyl]-1-piperidinyl]carbonyl]-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 14209980 | — |
| Reactant | Dimethyl[3-(piperidin-3-yl)propyl]amine | HCID 15057302 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4,9-Dihydro-4-[[3-[3-(dimethylamino)propyl]-1-piperidinyl]carbonyl]-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 14369674 | 35% |
Reaction Steps
Prepared analogously to Example 4 from 4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 3-[3-(dimethylamino)propyl]piperidine in a yield of 35% of theory. Colourless crystals, m.p. 137°-139° C. (acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-13f97e7b0e174c6b895d4a53e279311f |
| Source note | uspto-grants-1990_06 |