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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2106701Generated: October 30, 2026

11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one → 6,11-Dihydro-11-[[3-[2-(1-piperidinyl)ethyl]-1-piperidinyl]carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

https://huagongshe.com/reaction/2106701

Reaction equation

Participants

RoleNameHCIDCharge
Reactant11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-oneHCID 14209983—
Reactant1-[2-(3-Piperidinyl)ethyl]piperidineHCID 15057310—
SolventAcetonitrileHCID 6342—
Product6,11-Dihydro-11-[[3-[2-(1-piperidinyl)ethyl]-1-piperidinyl]carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-oneHCID 1436967050%

Reaction Steps

Prepared analogously to Example 4 from 11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one and 3-[2-(1-piperidinyl)ethyl]piperidine in a yield of 50% of theory. Colourless crystals, m.p. 168°-169° C. (acetonitrile).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04931436
Source datasetuspto-grants-1990_06
ORD IDord-9ba85767d8b5459abf13a5d64281e3b0
Source noteuspto-grants-1990_06