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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2106702Generated: October 30, 2026

11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one → 11-[[3-[2-(Diethylamino)ethyl]-1-piperidinyl]carbonyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

https://huagongshe.com/reaction/2106702

Reaction equation

Participants

RoleNameHCIDCharge
Reactant11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-oneHCID 14209983—
ReactantN,N-Diethyl-2-(3-piperidinyl)-1-ethanamineHCID 15057338—
SolventAcetonitrileHCID 6342—
Product11-[[3-[2-(Diethylamino)ethyl]-1-piperidinyl]carbonyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-oneHCID 1436967154%

Reaction Steps

Prepared analogously to Example 4 from 11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one and 3-[2-(diethylamino)ethyl]piperidine in a yield of 54% of theory. Colourless crystals, m.p. 110°-113° C. (acetonitrile).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04931436
Source datasetuspto-grants-1990_06
ORD IDord-336c93e5b3e4425c9fd727f3b4d0cf4a
Source noteuspto-grants-1990_06