HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one → 3-Methyl-4-[[4-[4-(1-piperidinyl)butyl]-1-piperidinyl]carbonyl]-4,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 14209980 | — |
| Reactant | 4-[4-(1-Piperidinyl)butyl]piperidine | HCID 14374292 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-Methyl-4-[[4-[4-(1-piperidinyl)butyl]-1-piperidinyl]carbonyl]-4,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 15057348 | 31% |
Reaction Steps
Prepared analogously to Example 4 from 4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 4-[4-(1-piperidinyl)butyl]piperidine in a yield of 31% of theory. Colourless crystals, m.p. 209°-210° C. (ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-a48fc4a14d0642938dc6849516db6619 |
| Source note | uspto-grants-1990_06 |