HuagongsheHuagongshe Chemistry Print Report · For research reference only
11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → 11-[[2-[2-[2-(Diethylamino)ethoxy]ethyl]-1-piperidinyl]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Reactant | 2-[2-[2-(Diethylamino)ethoxy]ethyl]piperidine | HCID 15057321 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 11-[[2-[2-[2-(Diethylamino)ethoxy]ethyl]-1-piperidinyl]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 15057331 | 79% |
Reaction Steps
Prepared analogously to Example 4 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[2-[2-(diethylamino)ethoxy]ethyl]piperidine (b.p.0.4 mmHg 95°-99° C.) in a yield of 79% of theory. Colourless crystals, m.p. 134°-136° C. (acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-f7135d11e81649668d58613db3a6c953 |
| Source note | uspto-grants-1990_06 |