HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 4-[[2-[2-[[2-(Diethylamino)ethyl]methylamino]ethyl]-1-piperidinyl]carbonyl]-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 4-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 14209980 | — |
| Reactant | 2-[2-[[2-(Diethylamino)ethyl]methylamino]ethyl]piperidine | HCID 15057322 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[[2-[2-[[2-(Diethylamino)ethyl]methylamino]ethyl]-1-piperidinyl]carbonyl]-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 15057346 | 22% |
Reaction Steps
Prepared analogously to Example 4, but using dichloromethane instead of acetonitrile as solvent, from 4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 2-[2-[[2-(diethylamino)ethyl]methylamino]ethyl]piperidine (b.p.0.3 mmHg 92°-95° C.) in a yield of 22% of theory. Colourless crystals, m.p. 131°-133° C. (acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-a6ad5e2da69546eea099c2f53aff027e |
| Source note | uspto-grants-1990_06 |