HuagongsheHuagongshe Chemistry Print Report · For research reference only
9-Chloro-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → 9-Chloro-11-[[4-[2-[2-(diethylamino)ethoxy]ethyl]-1-piperidinyl]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 9-Chloro-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 14209976 | — |
| Reactant | 4-[2-[2-(Diethylamino)ethoxy]ethyl]piperidine | HCID 15057325 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 9-Chloro-11-[[4-[2-[2-(diethylamino)ethoxy]ethyl]-1-piperidinyl]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 15057345 | 43% |
Reaction Steps
Prepared analogously to Example 4 from 9-chloro-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 4-[2-[2-(diethylamino)ethoxy]ethyl]piperidine in a yield of 43% of theory. Colourless crystals, m.p. 145°-146° C. (acetonitrile), Rf 0.39 (conditions as in Example 54).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931436 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-3a13f582272d4ae087b6c43793a74b1c |
| Source note | uspto-grants-1990_06 |