Hydrochloric Acid → 11-[[2-[2-[2-(Diethylamino)ethoxy]ethyl]-1-piperidinyl]carbonyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one	HCID 14209983	—
Reactant	2-[2-[2-(Diethylamino)ethoxy]ethyl]piperidine	HCID 15057321	—
Product	11-[[2-[2-[2-(Diethylamino)ethoxy]ethyl]-1-piperidinyl]carbonyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one	HCID 15057341	86%

Reaction Steps

Prepared analogously to Example 4 from 11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one and 2-[2-[2-(diethylamino)ethoxy]ethyl]piperidine in a yield of 86% of theory. The colourless hydrochloride melted at 186°-187° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04931436
Source dataset	uspto-grants-1990_06
ORD ID	ord-64ed62dd19f14b4a9d48fbb985a1e1d8
Source note	uspto-grants-1990_06