HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Nitro-3-(5,6,7,8-tetrahydro-1-naphthyloxy)pyridine-N-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 5,6,7,8-Tetrahydro-1-naphthol | HCID 68258 | — |
| Reactant | 3-Fluoro-4-nitropyridin-1-ium-1-olate | HCID 594028 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Nitro-3-(5,6,7,8-tetrahydro-1-naphthyloxy)pyridine-N-oxide | HCID 15068887 | — |
Reaction Steps
To 5,6,7,8-tetrahydro-1-naphthol (6.0 g) in DMF (100 ml) was added Na2CO3 (10 g) portionwise at room temperature. Then a solution of 3-fluoro-4-nitropyridine-N-oxide (6.0 g) in 20 ml of DMF was added dropwise and the mixture was stirred at room temperature for four hours. The mixture was then poured into water and extracted with ethyl acetate. The organic layer was washed with water and dried (sat NaCl, anhy. MgSO4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931457 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-d88116a2cd204992a095744afb38592c |
| Source note | uspto-grants-1990_06 |