反应详情

A suspension of 3-(2-naphthyloxy)-4-nitropyridine-N-oxide (8.5 g) in 250 ml ethanol containing 0.5 g platinum oxide was hydrogenated for 20 hours at 60 psi and thereafter filtered through Celite. The filtrate liquid was concentrated to 8.3 g oil. This oil was purified by flash chromatography (silica, ethyl acetate) to give a solid (7 g). This solid was recrystallized from anhydrous ether to give crystals, 4.6 g, mp 117°-118° C.

1. filtrationfiltered through Celite
2. concentrationThe filtrate liquid was concentrated to 8.3 g oil
3. customThis oil was purified by flash chromatography (silica, ethyl acetate)