反应详情

温度

80 °C

A mixture of 5 parts of N-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]thiourea, 3 parts of 2-chloro-1-phenylethanone, 1.7 parts of sodium acetate and 100 parts of acetic acid was stirred for 4 hours at 80° C. After cooling, the reaction mixture was evaporated and the residue was stirred in 130 parts of dichloromethane. The whole was neutralised with a sodium hydrogen carbonate solution. The precipitated product was filtered off, washed with water and dichloromethane and crystallized from 1,4-dioxane. The product was filtered off and dried, yielding 4.5 parts (69.6%) of N-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-4-phenyl-2-thiazolamine; mp. 269.7° C. (int. 2).

1. temperatureAfter cooling
2. customthe reaction mixture was evaporated
3. stirringthe residue was stirred in 130 parts of dichloromethane
4. filtrationThe precipitated product was filtered off
5. washwashed with water and dichloromethane
6. customcrystallized from 1,4-dioxane
7. filtrationThe product was filtered off
8. customdried