Hydrogen Bromide → HCID 23048860, compound

Participants

Reaction Steps

A mixture of 16 parts of 4,5-dihydro-2-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-5-methyl-4-propyl-3H-1,2,4-triazol-3-one and 375 parts of a hydrobromic acid solution 48% in water was stirred and refluxed for 4 hours. After cooling, the precipitated product was filtered off and dissolved in a mixture of methanol and water. The whole was neutralised with a sodium hydrogen carbonate solution. The precipitated product was filtered off and crystallized from 1,4-dioxane, yielding 13 parts (85%) of 4,5-dihydro-2-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5-methyl-4-propyl-3H-1,2,4-triazol-3-one; mp. 252.9° C. (compound 8.10).

Provenance & Evidence