Potassium Hydroxide → Methyl 3-amino-3-(3-nitrophenyl)prop-2-enoate

Participants

Reaction Steps

A mixture of dimethyl (α-amino-3-nitrobenzylidene)-malonate (120 g) and potassium hydroxide in a mixture of methanol (1.2 l) and water(120 ml) was refluxed for 8 hours. The reaction mixture was concentrated under reduced pressure to a volume of 200 ml. The resulting crystals were collected by filtration and recrystallized from methanol to give methyl 3-amino-3-(3-nitrophenyl)-acrylate (50.2 g).

Provenance & Evidence