HCID 10020712, compound → HCID 14051004, compound

HRID 2106819Notes

Reaction equation

HRID 2106819 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:13]=[N:12][C:11]=2[C:22]([O:24]CC)=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[NH3:27].CO>C(Cl)Cl>[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[C:14]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:13]=[N:12][C:11]=2[C:22]([NH2:27])=[O:24])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 10020712HCID 10020712, compoundHCID 21705897Ammonia methanol

Product 1

HCID 14051004HCID 14051004, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of ethyl 4-(3-nitrophenyl)-6-phenyl-3-pyridazinecarboxylate (1 g) in methylene chloride (10 ml) was added ammonia-methanol solution (60 ml) which was prepared by bubbling an ammonia gas (14 g) into methanol (120 ml), and the mixture was stirred for 24 hours at ambient temperature. After evaporating the solvent, the residue was recrystallized from methanol to give 4-(3-nitrophenyl)-6-phenyl-3-pyridazinecarboxamide (0.78 g).

Workup

  1. customwas prepared
  2. customby bubbling an ammonia gas (14 g) into methanol (120 ml)
  3. customAfter evaporating the solvent
  4. customthe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-da4e3eede8d74350bb8bdb138e74dedf
Source dataset
uspto-grants-1990_06
Patent number
US04931453

Reaction notes

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