1-Bromo-3-chloropropane → HCID 131716417, compound

Participants

Reaction Steps

36.4 g of 4-methyl-3-n-propylthio-phenol, 35 g of 3-bromo-1-chloro-n-propane and 3 g of tetrabutylammonium bromide were added into 10% aqueous solution of sodium hydroxide, and this mixture was stirred drastically for 2 hours at room temperature, then for 6 hours at 50° C. After the reaction was finished, the mixture was poured into 200 ml of water, and extracted 2 times by 200 ml of toluene. After the toluene layer was washed with water, toluene was distilled off, and the residue thus obtained was purified by silica-gel column chromatography (developing solvent: toluene+n-hexane) to give 40 g of the intended 1-chloro-3-(4-methyl-3-n-propylthiophenoxy)-n-propane (yield: 77.3%) as a colorless oil, nD25 1.5505.

Provenance & Evidence