1-Hexanol → 2-(Hexyloxy)thiophene

Participants

Reaction Steps

15 cm3 of 2-methoxythiophene were dissolved in 40 cm3 of n-hexanol and 30 cm3 of toluene, 1 g of NaHSO4 was added, and the mixture was refluxed for several hours. After distilling off 6 cm3 of an azeotrope of methanol and toluene, the residue was washed with sodium carbonate solution, dried and fractionated. 18 g of 2-hexyloxythiophene of b.p. 66° C./0.26 mbar were distilled off, 96% pure. Yield 65% of theory.

Provenance & Evidence