反应详情

Ethyl-12-(m-iodophenyl)-dodecanoate (7.17 g, 16.67 mmol), 95% ethanol (100 ml) and KOH (2.0 g) were placed into a 250 ml round-bottomed flask fitted with a reflux condenser. The reaction mixture was refluxed overnight. The ethanol was removed in vacuo and H2O was added. The aqueous solution was acidified and then extracted with ether. The ether layer was dried (MgSO4), and the solvent was evaporated to yield a yellow solid. The crude product was recrystallized with 95% ethanol to provide a white flaky solid, compound 7, 12-m-iodophenyldodecanoic acid (5.9 g, 88.0% yield).

1. customfitted with a reflux condenser
2. temperatureThe reaction mixture was refluxed overnight
3. customThe ethanol was removed in vacuo and H2O
4. additionwas added
5. extractionextracted with ether
6. dry with materialThe ether layer was dried (MgSO4)
7. customthe solvent was evaporated
8. customto yield a yellow solid
9. customThe crude product was recrystallized with 95% ethanol