Methyl Benzoate → HCID 19877240, compound

Participants

Reaction Steps

19.2 g of 3-ethyl-3-hydroxymethyl-8,10-diphenyl-1,5-dioxa-9-thiaspiro[5.5]-undecane and 6.8 g of methyl benzoate are dissolved in 100 ml of xylene. About 20 ml of xylene are distilled off under a weak stream of nitrogen. After cooling to 110°, 0.1 g of LiNH2 are added and the mixture is heated at 135° for 8 hours, with stirring, the methanol formed being continuously distilled off together with a little xylene. After cooling to room temperature, 0.25 ml of glacial acetic acid and 3 g of bleaching earth are added. After stirring for 15 minutes, the mixture is filtered. The filtrate is filtered over 100 g of silica gel and evaporated in vacuo. The oily residue is dried at 70° in vacuo. 3-Ethyl-3-benzoyloxymethyl-8,10-diphenyl-1,5-dioxa-9-thiaspiro[5.5]-undecane is obtained as a pale yellowish resin.

Provenance & Evidence