Acetic Anhydride → HCID 23047225, compound

Participants

Reaction Steps

Methyl 2-hydroxy-5-acetamidobenzoate (13.6 g, 68 mmole) was dissolved in pyridine (20 ml), acetic anhydride (7.4 ml) was added, and the reaction mixture was left at room temperature for 48 hours after which time it was evaporated to dryness, in vacuo. The remaining product was recrystallized from ethanol-water (1:3) to give the title compound (14.4 g, 84%), m.p. 133°-135° C. Found (Calc. for C12H13NO5) C 57.11 (57.37), H 5.28 (5.18), N 5.47 (5.58).

Provenance & Evidence