Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | HCID 14600609 | HCID 14600609 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 15052381 | HCID 15052381 | 62% |
Reaction Steps
320 mg of compound 1 was dissolved in chloroform and 10 ml of a solution of diazomethane in ether (about 0.5M) was added thereto dropwise at 0° C. After stirring at 0° C. for 6 hours, several drops of acetic acid were added thereto. After the completion of the reaction, the mixture was extracted with ether. The extract was concentrated and subjected to column chyromatography (silica gel, ethyl acetate: hexane=1:5-1:4). As a result, 206 mg of the desired compound was obtained (yield: 62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04933329 |
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| Source dataset | uspto-grants-1990_06 |
|---|
| ORD ID | ord-f80675b6417f42c49149b4ebcbe68e86 |
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| Source note | uspto-grants-1990_06 |
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