Dimethylformamide → HCID 23047240, compound

Participants

Reaction Steps

0.76 g (19 mmol) washed potassium hydride, 75 ml dry DMF and 3 g (9.5 mmol) 5'-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-spiro-[cyclopentane-1, 3'-[3H]-indol]-2'(1'H)-one (Example 6) were stirred at room temperature during 30mn. 2.8 g (20 mmol) methyliodide were added and the stirring was continued for 1 hr. 150 ml water were added and the mixture was extracted with ethyl acetate. The organic layer was dried over magnesium sulfate. The crude product was purified by column chromatography on silica (eluent:methylen chloride/methanol: 99.5/0.5).

Provenance & Evidence