Nicotinoyl chloride → HCID 23047258, compound

HRID 2107040Notes

Reaction equation

[CH3:1][CH:2]1[S:7][C:6](=[O:8])[NH:5][N:4]=[C:3]1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][C:13](=[O:18])[C:12]2([CH3:20])[CH3:19].[C:21](Cl)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[N:24][CH:23]=1>>[CH3:1][CH:2]1[S:7][C:6](=[O:8])[NH:5][N:4]=[C:3]1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([C:21]([C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1)=[O:28])[C:13](=[O:18])[C:12]2([CH3:19])[CH3:20]

Participants

Reactant 2

HCID 82604Nicotinoyl chloride

HCID 15111517HCID 15111517, compound

Product 1

HCID 23047258HCID 23047258, compoundYield 55%

Procedure

Starting from 1,3-dihydro-5(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4 thiadiazin-5-yl)-3,3 dimethyl-2H-indol-2-one (Example 3) and according to the method described in Example 23, but using nicotinoyl chloride instead of isonicotinoyl chloride, afforded the desired compound.

Sources & evidence

ORD record: ord-1cc4ed9e97754403835d472f3e524965
Source dataset: uspto-grants-1990_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04933336

Reaction notes

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