Tetrafluoroboric acid → HCID 12472226, compound

Participants

Reaction Conditions

Reaction Steps

An aqueous solution of fluoroboric acid (48% w/v; 33 ml) was added to a stirred solution of 1-cyano-2-isobutyryl-1,2-dihydroisoquinoline (6.78 g; prepared according to the method described by F. D. Popp and A. Soto, J. Chem. Soc., 1963, 1760) in acetic acid (25 ml) at 60° C. The solution was stirred for 15 minutes and then cooled to 5° C. The solid was collected, washed thoroughly with diethyl ether and dried, to give 1-amino-3-isopropyloxazolo[4,3-a]isoquinolinium tetrafluoroborate (8.55 g) in the form of a pale yellow solid, m.p. 181°-183° C. [Elemental analysis: C, 53.0; H, 4.78; N, 8.9%; Calculated: C, 53.5; H, 4.81; N, 8 9%; N.M.R. in CD3CN): 1.44 (6H, d, J=7 Hz), 3.68 (1H, septet, J=7 Hz), 5.90 (2H, broad s), 7.27 (1H, d, J=8 Hz), 7.48-7.72 (4H, m), 7.92 (1H, d, J=8 Hz); Mass spectrum (fast atom bombardment) m/e=227].

Provenance & Evidence