HCID 86744006, compound → HCID 23047442, compound

Participants

Reaction Steps

A solution of ethyl (E)-5-hydroxy-7-(3-isopropyl-1-phenylpyrrolo[2,1-a]isoquinolin-2-yl)-3-oxohept-6-enoate (0.94 g; prepared as described in Reference Example 2) in ethanol (42 ml) was reduced catalytically under a hydrogen atmosphere using 5% w/w palladium on charcoal (0.254 g) and 5% w/w palladium on calcium carbonate (0.226 g) as catalysts. The mixture was filtered to remove the catalysts and the filtrate was evaporated, to give ethyl 5-hydroxy-7-(3-isopropyl1-phenylpyrrolo[2,1-a]isoquinolin-2-yl)-3-oxoheptanoate (0.98 g) in the form of a pale green gum.

Provenance & Evidence