4-Acetyl-3-hydroxy-2-propylbenzyl chloride → 2-[(4-Acetyl-3-hydroxy-2-propylbenzyl)thio]-3-hydroxypyridine

HRID 2107103Notes

Reaction equation

HRID 2107103 reaction equation
[C:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[C:6]([CH2:12][CH2:13][CH3:14])[C:5]=1[OH:15])(=[O:3])[CH3:2].[OH:16][C:17]1[C:18]([SH:23])=[N:19][CH:20]=[CH:21][CH:22]=1>>[C:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][S:23][C:18]2[C:17]([OH:16])=[CH:22][CH:21]=[CH:20][N:19]=2)=[C:6]([CH2:12][CH2:13][CH3:14])[C:5]=1[OH:15])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 137810224-Acetyl-3-hydroxy-2-propylbenzyl chlorideHCID 178516238HCID 178516238, compound

Product 1

HCID 140531382-[(4-Acetyl-3-hydroxy-2-propylbenzyl)thio]-3-hydroxypyridineYield 78.6%

Procedure

Using as starting materials 0.30 g of 4-acetyl-3-hydroxy-2-propylbenzyl chloride and 0.25 g of 3-hydroxy-2-mercaptopyridine, 0.33 g of 2-[(4-acetyl-3-hydroxy-2-propylbenzyl)thio]-3-hydroxypyridine was obtained in a manner similar to Example 14.

Sources & evidence

ORD record
ord-d03052533412400e86ecaa591ba81842
Source dataset
uspto-grants-1990_06
Patent number
US04933348

Reaction notes

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