4-Hydroxybenzyl Alcohol → Ethyl 2-[4-(hydroxymethyl)phenoxy]propanoate

HRID 2107108Notes

Reaction equation

HRID 2107108 reaction equation
[CH:1]1[C:6]([CH2:7][OH:8])=[CH:5][CH:4]=[C:3]([OH:9])[CH:2]=1.Br[CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13]>>[OH:8][CH2:7][C:6]1[CH:5]=[CH:4][C:3]([O:9][CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:2][CH:1]=1

Participants

3

Reactant 2

HCID 1254-Hydroxybenzyl AlcoholHCID 79040Ethyl 2-bromopropionate

Product 1

HCID 19800931Ethyl 2-[4-(hydroxymethyl)phenoxy]propanoateYield 79.7%

Procedure

Using as starting materials 1.00 g of p-hydroxybenzyl alcohol and 1.61 g of ethyl 2-bromopropionate, 1.44 g of ethyl 2-[p-(hydroxymethyl)phenoxy]propionate was obtained in a manner similar to Reference Example 2.

Sources & evidence

ORD record
ord-13c301e7986b4b0ea31d28826d3a84c8
Source dataset
uspto-grants-1990_06
Patent number
US04933348

Reaction notes

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