Acetyl chloride → HCID 86744010, compound

HRID 2107121Notes

Reaction equation

HRID 2107121 reaction equation
Cl.[CH3:2][NH:3][C@H:4]([C:7]([OH:9])=[O:8])[CH2:5][Cl:6].[C:10](Cl)(=[O:12])[CH3:11]>C1(C)C=CC=CC=1>[CH3:2][N:3]([C:10](=[O:12])[CH3:11])[C@H:4]([C:7]([OH:9])=[O:8])[CH2:5][Cl:6]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 86744011HCID 86744011, compound

Product 1

HCID 86744010HCID 86744010, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

181 g of methyl 3-chloroalanine hydrochloride were heated under reflux with 163.9 g of acetyl chloride in 1.5 l of anhydrous toluene for about 5 hours until a clear solution was obtained. This was evaporated to dryness and the residue was crystallized from ethyl acetate/petroleum ether. 170 g of product of m.p. 104° C. were obtained.

Workup

  1. customwas obtained
  2. customThis was evaporated to dryness
  3. customthe residue was crystallized from ethyl acetate/petroleum ether

Sources & evidence

ORD record
ord-6ced13faf29341869a22cf92ed5a3d99
Source dataset
uspto-grants-1990_06
Patent number
US04933361

Reaction notes

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