HRID2107165

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8082

Piperidine

C5H11N

HCID79793

3-Thiazolidineacetic acid, 4-oxo-2-thioxo-

C5H5NO3S2

结构：O=Cc1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1

HCID15053569

未命名化合物

PRODUCTS

生成物

结构：C1CC[NH2+]CC1.O=C([O-])CN1C(=O)C(=Cc2csc(NC(c3ccccc3)(c3ccccc3)c3ccccc3)n2)SC1=S

HCID74015737

未命名化合物

收率 101.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture comprising 2.5 g of 2-tritylaminothiazole-4-carbaldehyde, 0.81 g of rhodanine-3-acetic acid, 1.1 g of piperidine and 25 ml of ethanol was stirred at room temperature for 7 hours. The crystalline product which precipitated out was collected by filtration and washed with methanol, to obtain 2.7 g of the desired compound as a yellowish-brown powder.

WORKUP

后处理

customThe crystalline product which precipitated out
filtrationwas collected by filtration
washwashed with methanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-41f04f5b11a54eadae53e166c78e148a
来源数据集: uspto-grants-1990_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04933355
来源说明: uspto-grants-1990_06

反应 SMILES

[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([CH:26]=O)[N:25]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:28]1[CH2:34][C:32](=[O:33])[N:31]([CH2:35][C:36]([OH:38])=[O:37])[C:29]1=[S:30].[NH:39]1[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]1>C(O)C>[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([CH:26]=[C:34]2[S:28][C:29](=[S:30])[N:31]([CH2:35][C:36]([O-:38])=[O:37])[C:32]2=[O:33])[N:25]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2+:39]1[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]1