Hydrochloric Acid → HCID 53922348, compound

Participants

Reaction Steps

A mixture comprising 2 g of 5-[1-(2-aminothiazol-4-yl)-1-ethoxycarbonylmethylene]rhodanine-3-acetic acid monohydrate, 3 g of benzyl bromide, 1.1 g of triethylamine and 10 ml of hexamethylphosphoric triamide was stirred at room temperature for 16 hours. The reaction mixture was acidified with dilute hydrochloric acid and then extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and the solvent was evaporated off under reduced pressure. The residue was purified by silica gel column chromatography using as eluent a 8:2:1 by volume mixture of hexane, ethyl acetate and acetic acid, giving the desired compound as yellow crystals.

Provenance & Evidence