Phenyl isocyanate → HCID 53804008, compound

HRID 2107181Notes

Reaction equation

HRID 2107181 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[C:11]2[S:15][C:14](=[S:16])[N:13]([CH2:17][C:18]([OH:20])=[O:19])[C:12]2=[O:21])[C:8]([OH:10])=[O:9])[N:6]=1.[C:22]1([N:28]=[C:29]=[O:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>CN(C)P(=O)(N(C)C)N(C)C>[C:8]([C:7](=[C:11]1[S:15][C:14](=[S:16])[N:13]([CH2:17][C:18]([OH:20])=[O:19])[C:12]1=[O:21])[C:5]1[N:6]=[C:2]([NH:1][C:29]([NH:28][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:30])[S:3][CH:4]=1)([OH:10])=[O:9]

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 53667546HCID 53667546, compound

Product 1

HCID 53804008HCID 53804008, compound

Reagents, catalysts & solvents 1

HCID 12679HexamethylphosphoramideSolvent

Procedure

Following a procedure similar to that described in Preparation 1, the desired compound was prepared from 1 g of 5-[1-(2-aminothiazol-4-yl)-1-carboxymethylene]rhodanine-3-acetic acid, 3.9 g of phenyl isocyanate and 10 ml of hexamethylphosphoric triamide. The resulting product was a ellow powder having the following physical properties.

Workup

  1. customthat described in Preparation 1

Sources & evidence

ORD record
ord-f31eec2ea02843c8b832760ef1fd2782
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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