Ammonia → HCID 131716431, compound

HRID 2107185Notes

Reaction equation

HRID 2107185 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:13][C:14](=[O:28])[NH:15][C:16]2[S:17][CH:18]=[C:19]([C:21](=O)[C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:20]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[S:29]1[CH2:35][C:33](=[O:34])[N:32]([CH2:36][C:37]([OH:39])=[O:38])[C:30]1=[S:31].[Cl-].[NH4+].N>C(O)C>[OH2:2].[CH2:25]([O:24][C:22]([C:21](=[C:35]1[S:29][C:30](=[S:31])[N:32]([CH2:36][C:37]([OH:39])=[O:38])[C:33]1=[O:34])[C:19]1[N:20]=[C:16]([NH:15][C:14]([NH:13][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=2)=[O:28])[S:17][CH:18]=1)=[O:23])[CH3:26].[OH2:2].[OH2:2].[CH2:25]([O:24][C:22]([C:21](=[C:35]1[S:29][C:30](=[S:31])[N:32]([CH2:36][C:37]([OH:39])=[O:38])[C:33]1=[O:34])[C:19]1[N:20]=[C:16]([NH:15][C:14]([NH:13][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=2)=[O:28])[S:17][CH:18]=1)=[O:23])[CH3:26]

Participants

6

Reactant 4

HCID 222AmmoniaHCID 25517Ammonium ChlorideHCID 797933-Thiazolidineacetic acid, 4-oxo-2-thioxo-HCID 15053517HCID 15053517, compound

Product 1

HCID 131716431HCID 131716431, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following a procedure similar to that described in Example 1, the desired compound was prepared from 1.1 g of ethyl 2-[3-(3,4,5-trimethoxyphenyl)ureido]thiazol-4-ylglyoxylate. 0.48 9 of rhodanine-3-acetic acid. 0.25 g of ammonium chloride. 0.25 ml of 28% v/v aqueous ammonia and ml of ethanol, in the form of brown prismatic crystals having the following physical properties.

Sources & evidence

ORD record
ord-b94bda199d574bc088f505da067a2306
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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