Ammonia → HCID 86744029, compound

HRID 2107190Notes

Reaction equation

HRID 2107190 reaction equation
[CH2:1]([NH:8][C:9](=[O:23])[NH:10][C:11]1[S:12][CH:13]=[C:14]([C:16](=O)[C:17]([O:19][CH2:20][CH3:21])=[O:18])[N:15]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:24]1[CH2:30][C:28](=[O:29])[N:27]([CH2:31][C:32]([OH:34])=[O:33])[C:25]1=[S:26].[Cl-].[NH4+].N>C(O)C>[OH2:18].[OH2:29].[CH2:1]([NH:8][C:9](=[O:23])[NH:10][C:11]1[S:12][CH:13]=[C:14]([C:16](=[C:30]2[S:24][C:25](=[S:26])[N:27]([CH2:31][C:32]([OH:34])=[O:33])[C:28]2=[O:29])[C:17]([O:19][CH2:20][CH3:21])=[O:18])[N:15]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 25517Ammonium ChlorideHCID 797933-Thiazolidineacetic acid, 4-oxo-2-thioxo-HCID 15053519HCID 15053519, compound

Product 1

HCID 86744029HCID 86744029, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following a procedure similar to that described in Example 1, the desired compound was prepared from 1.67 g of ethyl 2-(3-benzylureido)thiazol-4-ylglyoxylate, 0.95 g of rhodanine-3-acetic acid, 0.5 g of ammonium chloride, 0.5 ml of 28% v/v aqueous ammonia and 25 ml of ethanol. The resulting product was a yellow powder having the following physical properties.

Sources & evidence

ORD record
ord-5c35847e1add4d0ab0aac5fa6c2b7a32
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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