Ammonia → HCID 131716433, compound

HRID 2107192Notes

Reaction equation

HRID 2107192 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:20])[NH:10][C:11]2[S:12][CH:13]=[C:14](/[CH:16]=[CH:17]/[CH:18]=[O:19])[N:15]=2)=[CH:4][CH:3]=1.[S:21]1[CH2:27][C:25](=[O:26])[N:24]([CH2:28][C:29]([OH:31])=[O:30])[C:22]1=[S:23].[Cl-].[NH4+].N>C(O)C>[OH2:19].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:20])[NH:10][C:11]2[S:12][CH:13]=[C:14](/[CH:16]=[CH:17]/[CH:18]=[C:27]3[S:21][C:22](=[S:23])[N:24]([CH2:28][C:29]([OH:31])=[O:30])[C:25]3=[O:26])[N:15]=2)=[CH:4][CH:3]=1.[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:20])[NH:10][C:11]2[S:12][CH:13]=[C:14](/[CH:16]=[CH:17]/[CH:18]=[C:27]3[S:21][C:22](=[S:23])[N:24]([CH2:28][C:29]([OH:31])=[O:30])[C:25]3=[O:26])[N:15]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 25517Ammonium ChlorideHCID 797933-Thiazolidineacetic acid, 4-oxo-2-thioxo-HCID 15053525HCID 15053525, compound

Product 1

HCID 131716433HCID 131716433, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following a procedure similar to that described in Example 1, the desired compound was prepared using 0.4 g of (E)-3-[2-(3-p-bromophenylureido)thiazol-4-yl]acrylaldehyde, 0.2 g of rhodanine-3-acetic acid, 0.15 g of ammonium chloride, 0.15 ml of 28% v/v aqueous ammonia and 10 ml of ethanol. The resulting product was a brownish-orange powder having the following physical properties.

Sources & evidence

ORD record
ord-5f24c0872ed14219ac1cb469da8b1dc1
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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