Ammonia → 5(2-Morpholinothiazol-4-ylmethylene)rhodanine-3-acetic acid

HRID 2107215Notes

Reaction equation

HRID 2107215 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[S:8][CH:9]=[C:10]([CH:12]=O)[N:11]=2)[CH2:3][CH2:2]1.[S:14]1[CH2:20][C:18](=[O:19])[N:17]([CH2:21][C:22]([OH:24])=[O:23])[C:15]1=[S:16].[Cl-].[NH4+].N>C(O)C>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[S:8][CH:9]=[C:10]([CH:12]=[C:20]3[S:14][C:15](=[S:16])[N:17]([CH2:21][C:22]([OH:24])=[O:23])[C:18]3=[O:19])[N:11]=2)[CH2:5][CH2:6]1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 25517Ammonium ChlorideHCID 797933-Thiazolidineacetic acid, 4-oxo-2-thioxo-HCID 150535792-(Morpholin-4-yl)-1,3-thiazole-4-carbaldehyde

Product 1

HCID 536334635(2-Morpholinothiazol-4-ylmethylene)rhodanine-3-acetic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The reaction described in Example 1 was repeated, but using 1.65 g of 2-morpholinothiazole-4-carbaldehyde, 1.3 g of rhodanine-3-acetic acid, 1g of ammonium chloride, 1 ml of 28% v/v aqueous ammonia and 35 ml of ethanol, giving the title compound as yellow needles.

Sources & evidence

ORD record
ord-783f4e5138f84a92869f1110e00b3d72
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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