Ammonia → HCID 54385437, compound

HRID 2107219Notes

Reaction equation

HRID 2107219 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[S:9][CH:10]=[C:11]([CH:13]=O)[N:12]=2)[CH2:4][CH2:3]1.[S:15]1[CH2:21][C:19](=[O:20])[N:18]([CH2:22][C:23]([OH:25])=[O:24])[C:16]1=[S:17].[Cl-].[NH4+].N>C(O)C>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[S:9][CH:10]=[C:11]([CH:13]=[C:21]3[S:15][C:16](=[S:17])[N:18]([CH2:22][C:23]([OH:25])=[O:24])[C:19]3=[O:20])[N:12]=2)[CH2:6][CH2:7]1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 25517Ammonium ChlorideHCID 797933-Thiazolidineacetic acid, 4-oxo-2-thioxo-HCID 15053582HCID 15053582, compound

Product 1

HCID 54385437HCID 54385437, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The reaction described in Example 1 was repeated, but using 1.8 g of 2-(4-methyl-1-piperazinyl)thiazole-4-carbaldehyde, 1.2 g of rhodanine-3-acetic acid, 0.9 g of ammonium chloride, 0.9 ml of 28% v/v aqueous ammonia, and 40 ml of ethanol, giving the title compound as dark yellow needles.

Sources & evidence

ORD record
ord-c93cb866df184ea9942ce5bd8c8344b2
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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