Methanol → 2-(3-Phenylureido)thiazole-4-carbaldehyde

HRID 2107236Notes

Reaction equation

HRID 2107236 reaction equation
I([O-])(=O)(=O)=O.[Na+].[OH:7][CH:8]([C:11]1[N:12]=[C:13]([NH:16][C:17]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:18])[S:14][CH:15]=1)CO.CO>O>[C:20]1([NH:19][C:17](=[O:18])[NH:16][C:13]2[S:14][CH:15]=[C:11]([CH:8]=[O:7])[N:12]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 150535134-(1,2-Dihydroxyethyl)-2-(3-phenylureido)thiazoleHCID 23667635Sodium periodate

Product 1

HCID 150535142-(3-Phenylureido)thiazole-4-carbaldehyde

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 0.76 g of sodium metaperiodate in 15 ml of water was added dropwise at room temperature to a mixture comprising 0.5 g of 4-(1,2-dihydroxyethyl)-2-(3-phenylureido)thiazole and 15 ml of methanol, and the mixture was stirred for 2 hours after completion of the dropwise addition. The solvent was then evaporated off under reduced pressure and the residue was washed with water, giving the desired compound as a white powder.

Workup

  1. additionafter completion of the dropwise addition
  2. customThe solvent was then evaporated off under reduced pressure
  3. washthe residue was washed with water

Sources & evidence

ORD record
ord-9904b6e62cfb41e9b34c048d856fe5f1
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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