Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → HCID 15053524, compound

Participants

Reaction Steps

Following a procedure similar to that described in Preparation 48, crude ethyl 3-[2-(3-p-bromophenylureido)thiazol-4-yl]acrylate was prepared from 1 g of 2-(3-p-bromophenylureido)thiazole-4-carbaldehyde, 1.2 g of ethoxycarbonylmethylenetriphenylphosphorane and 20 ml of tetrahydrofuran. Subsequently. following a procedure similar to that described in Preparation 49, the desired compound was prepared from 1.1 g of the above crude ethyl ester, 14 ml of a 1M hexane solution of diisobutyl aluminum hydride and 30 ml of tetrahydrofuran. The resulting product was a white powder having the following physical properties.

Provenance & Evidence