Water → 2-Diphenylmethylaminothiazole-4-carbaldehyde

HRID 2107272Notes

Reaction equation

HRID 2107272 reaction equation
[C:1]1([CH:7]([NH:14][C:15]2[S:16][CH:17]=[C:18]([CH:20]([OH:23])CO)[N:19]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.I([O-])(=O)(=O)=O.[Na+].O>CO>[C:8]1([CH:7]([NH:14][C:15]2[S:16][CH:17]=[C:18]([CH:20]=[O:23])[N:19]=2)[C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 962WaterHCID 23047617HCID 23047617, compoundHCID 23667635Sodium periodate

Product 1

HCID 230476352-Diphenylmethylaminothiazole-4-carbaldehyde

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Following a procedure similar to that described in Preparation 50, the desired compound was prepared from 2.11 g of 1-(2-diphenylmethylaminothiazol-4-yl)ethane-1,2-diol, 3.15 g of sodium metaperiodate, 40 ml of water and 20 ml of methanol. The resulting product was a pale brown foam having the following physical properties.

Workup

  1. customthat described in Preparation 50

Sources & evidence

ORD record
ord-1142b61048cf4ae3906db24677406ee9
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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