HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-p-Fluoroanilinothiazol-4-ylmethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Ethyl 4-((4-fluorophenyl)amino)-3,5-thiazolecarboxylate | HCID 15053539 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-p-Fluoroanilinothiazol-4-ylmethanol | HCID 15053555 | — |
Reaction Steps
The reaction described in Preparation 50 was repeated, but using 12.04 g of ethyl 2-p-fluoroanilinothiazole-4-carboxylate, 6 g of sodium borohydride, 120 ml of anhydrous tetrahydrofuran, and 70 ml of absolute methanol, giving the title compound as colorless prisms.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04933355 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-0f39d68bf59145b49dc6a5d1ee16aba7 |
| Source note | uspto-grants-1990_06 |