Ethyl bromopyruvate → 4-Thiazolecarboxylic acid, 2-(ethylamino)-, ethyl ester

HRID 2107278Notes

Reaction equation

HRID 2107278 reaction equation
[CH2:1]([NH:3][C:4]([NH2:6])=[S:5])[CH3:2].Br[CH2:8][C:9](=O)[C:10]([O:12][CH2:13][CH3:14])=[O:11]>C(O)C>[CH2:1]([NH:3][C:4]1[S:5][CH:8]=[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:6]=1)[CH3:2]

Participants

4

Reactant 2

HCID 66144Ethyl bromopyruvateHCID 3032338Ethylthiourea

Product 1

HCID 150535414-Thiazolecarboxylic acid, 2-(ethylamino)-, ethyl ester

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The reaction described in Preparation 42 was repeated but using 10 g of ethylthiourea, 20 g of ethyl bromopyruvate and 100 ml of ethanol, giving the title compound as a pale yellow powder.

Workup

  1. customThe reaction described in Preparation 42

Sources & evidence

ORD record
ord-5720cd20ce9a47fab55608c988cdc9d7
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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