Benzene → Ethyl 2-(piperidin-1-yl)-1,3-thiazole-4-carboxylate

Participants

Reaction Steps

A mixture comprising 2.1 g of piperidine, 4 g of ethyl 2-chlorothiazole-4-carboxylate, 4.2 g of triethylamine and 20 ml of benzene was refluxed for 12 hours. The reaction mixture was poured into water and extracted with benzene. The extract was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure.

Provenance & Evidence